| Literature DB >> 19429886 |
Gissette Reyes-Soffer1, Steve Holleran, Wahida Karmally, Colleen I Ngai, Niem-Tzu Chen, Margarita Torres, Rajasekhar Ramakrishnan, William S Blaner, Lars Berglund, Henry N Ginsberg, Catherine Tuck.
Abstract
Individuals with type 2 diabetes mellitus (DM) characteristically have elevated fasting and postprandial (PP) plasma triglycerides (TG). Previous case-control studies indicated that PPTG levels predict the presence of coronary artery disease (CAD) in people without DM; however, the data for patients with DM are conflicting. Therefore, we conducted a case-control study in DM individuals, 84 with (+) and 80 without (-) CAD. Our hypothesis was that DM individuals with or without CAD would have similar PPTG levels, but CAD+ individuals would have more small d<1.006 g/L lipoprotein particles. Several markers of PP lipid metabolism were measured over 10 h after a fat load. PP lipoprotein size and particle number were also determined. There was no significant difference in any measure of PP lipid metabolism between CAD+ and CAD-, except for apoB48, which was actually higher in CAD-. We followed 69 CAD- participants for a mean 8.7 years; 33 remained free of any cardiovascular event. There were no PP differences at baseline between these 33 who remained CAD- and either the 36 original CAD- who subsequently developed CAD or the original CAD+ group.PP measurements of TG-rich lipoproteins do not predict the presence of CAD in individuals with DM.Entities:
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Year: 2009 PMID： 19429886 PMCID： PMC2724776 DOI： 10.1194/jlr.M900092-JLR200
Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922