| Literature DB >> 19429511 |
Mark J Gemkow1, Adam J Davenport, Silke Harich, Bart A Ellenbroek, Andrea Cesura, David Hallett.
Abstract
The histamine H3 receptor plays a regulatory role in the pre-synaptic release of histamine and other neurotransmitters, making it an attractive target for CNS indications including cognitive disorders, narcolepsy, ADHD and pain. As more and more H3 antagonists/H3 inverse agonists progress through the clinic, knowledge is gained to define the profile of the 'ideal' compound in terms of specificity, pharmacokinetic parameters and both duration and magnitude of receptor occupancy. Whether a single compound profile for the treatment of different disorders can be defined remains to be seen.Entities:
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Year: 2009 PMID： 19429511 DOI： 10.1016/j.drudis.2009.02.011
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851