Literature DB >> 19429505

Application of LC/MS to proteomics studies: current status and future prospects.

Guodong Chen1, Birendra N Pramanik.   

Abstract

Liquid chromatography/mass spectrometry (LC/MS) has become a powerful technology in proteomics studies in drug discovery, including target protein characterization and discovery of biomarkers. This review article will describe current LC/MS approaches in protein characterization, including a bottom-up method for protein identification and quantitative proteomics. We will discuss the investigation of protein post-translational modifications such as glycosylation (glycoproteomics) and phosphorylation (phosphoproteomics) using LC/MS. Future trends in LC/MS with respect to proteomics studies will also be illustrated.

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Year:  2009        PMID： 19429505     DOI： 10.1016/j.drudis.2009.02.007

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  13 in total

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