| Literature DB >> 19428560 |
Adriana Arena1, Concetta Gugliandolo, Giovanna Stassi, Bernadette Pavone, Daniela Iannello, Giuseppe Bisignano, Teresa Luciana Maugeri.
Abstract
The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. In fact, high levels of IFN-alpha, IL-12, IFN-gamma, TNF-alpha, IL-18 were detected in supernatants of EPS-2 treated PBMC. Moreover, this effect was dose-dependent. Taken together, our results confirm that the immunological disorders determined by HSV-2 could be partially restored by treatment with EPS-2.Entities:
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Year: 2009 PMID： 19428560 DOI： 10.1016/j.imlet.2009.03.001
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685