Literature DB >> 19427861

Functional dissection of the intramolecular Src homology 3-guanylate kinase domain coupling in voltage-gated Ca2+ channel beta-subunits.

Yu-hang Chen1, Lin-ling He, Douglas R Buchanan, Yun Zhang, Aileen Fitzmaurice, Jian Yang.   

Abstract

The beta-subunit of voltage-gated Ca(2+) channels is essential for trafficking the channels to the plasma membrane and regulating their gating. It contains a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain, which interact intramolecularly. We investigated the structural underpinnings of this intramolecular coupling and found that in addition to a previously described SH3 domain beta strand, two structural elements are crucial for maintaining a strong and yet potentially modifiable SH3-GK intramolecular coupling: an intrinsically weak SH3-GK interface and a direct connection of the SH3 and GK domains. Alterations of these elements uncouple the two functions of the beta-subunit, degrading its ability to regulate gating while leaving its chaperone effect intact.

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Year:  2009        PMID： 19427861      PMCID： PMC2739582          DOI： 10.1016/j.febslet.2009.05.001

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  36 in total

1.  The [beta]2a subunit is a molecular groom for the Ca2+ channel inactivation gate.

Authors:  S Restituito; T Cens; C Barrere; S Geib; S Galas; M De Waard; P Charnet
Journal:  J Neurosci       Date:  2000-12-15       Impact factor: 6.167

Review 2.  Structure and regulation of voltage-gated Ca2+ channels.

Authors:  W A Catterall
Journal:  Annu Rev Cell Dev Biol       Date:  2000       Impact factor: 13.827

3.  Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.

Authors:  A W McGee; S R Dakoji; O Olsen; D S Bredt; W A Lim; K E Prehoda
Journal:  Mol Cell       Date:  2001-12       Impact factor: 17.970

4.  Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca2+ channel gating.

Authors:  Thomas D Helton; William A Horne
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

5.  Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on L-type calcium channel gating.

Authors:  Shoji X Takahashi; Scott Mittman; Henry M Colecraft
Journal:  Biophys J       Date:  2003-05       Impact factor: 4.033

6.  A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channels.

Authors:  L Berrou; H Klein; G Bernatchez; L Parent
Journal:  Biophys J       Date:  2002-09       Impact factor: 4.033

7.  Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Authors:  Jérôme Leroy; Mark W Richards; Mark S Richards; Adrian J Butcher; Manuela Nieto-Rostro; Wendy S Pratt; Anthony Davies; Annette C Dolphin
Journal:  J Neurosci       Date:  2005-07-27       Impact factor: 6.167

8.  Alternative splicing of a beta4 subunit proline-rich motif regulates voltage-dependent gating and toxin block of Cav2.1 Ca2+ channels.

Authors:  Thomas D Helton; Douglas J Kojetin; John Cavanagh; William A Horne
Journal:  J Neurosci       Date:  2002-11-01       Impact factor: 6.167

9.  An intramolecular interaction between Src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90.

Authors:  H Shin; Y P Hsueh; F C Yang; E Kim; M Sheng
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

10.  Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95.

Authors:  G A Tavares; E H Panepucci; A T Brunger
Journal:  Mol Cell       Date:  2001-12       Impact factor: 17.970
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  8 in total

Review 1.  The ß subunit of voltage-gated Ca2+ channels.

Authors:  Zafir Buraei; Jian Yang
Journal:  Physiol Rev       Date:  2010-10       Impact factor: 37.312

2.  Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.

Authors:  Li Li; De-Pei Li; Shao-Rui Chen; Jinjun Chen; Hongzhen Hu; Hui-Lin Pan
Journal:  Mol Pharmacol       Date:  2014-09-29       Impact factor: 4.436

Review 3.  Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.

Authors:  Daniel L Minor; Felix Findeisen
Journal:  Channels (Austin)       Date:  2010 Nov-Dec       Impact factor: 2.581

4.  A quartet of leucine residues in the guanylate kinase domain of CaVβ determines the plasma membrane density of the CaV2.3 channel.

Authors:  Behzad Shakeri; Benoîte Bourdin; Pierre-Olivier Demers-Giroux; Rémy Sauvé; Lucie Parent
Journal:  J Biol Chem       Date:  2012-07-30       Impact factor: 5.157

Review 5.  Structure and function of the β subunit of voltage-gated Ca²⁺ channels.

Authors:  Zafir Buraei; Jian Yang
Journal:  Biochim Biophys Acta       Date:  2012-09-07

6.  Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels.

Authors:  Jean-Sebastien Rougier; Maxime Albesa; Hugues Abriel; Patricia Viard
Journal:  J Biol Chem       Date:  2011-01-10       Impact factor: 5.157

7.  The HOOK region of voltage-gated Ca2+ channel β subunits senses and transmits PIP2 signals to the gate.

Authors:  Cheon-Gyu Park; Yongsoo Park; Byung-Chang Suh
Journal:  J Gen Physiol       Date:  2017-01-13       Impact factor: 4.086

8.  Inhibitory effects on L- and N-type calcium channels by a novel CaVβ1 variant identified in a patient with autism spectrum disorder.

Authors:  Patrick Despang; Sarah Salamon; Alexandra Breitenkamp; Elza Kuzmenkina; Jan Matthes
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-02-05       Impact factor: 3.000
  8 in total

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