| Literature DB >> 19427773 |
H Lü1, J Chen, W L Li, B R Ren, J L Wu, H Q Zhang.
Abstract
The antidiabetic effect of the total flavonoids fraction from leaves of Eriobotrya japonica (EJF) was evaluated through normal and streptozotocin-induced diabetic mice with graded oral doses of 150, 300, 450 mg/kg for 7 days or 14 days. The result showed that the dose of 300 mg/kg and 450 mg/kg resulted significant hypoglycemic effect on normal mice, the dose of 300 mg/kg induced significant decrease in plasma glucose concentration (PGC), glycosylated serum protein (GSP), total cholesterol (TC) and triglyceride (TG), and significant increase in superoxide dismutase (SOD) activity and serum insulin level in streptozotocin-diabetic mice. These results suggested that EJF has hypoglycemic potential.Entities:
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Year: 2009 PMID： 19427773 DOI： 10.1016/j.phymed.2009.03.024
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340