| Literature DB >> 19427022 |
Guilin Tang1, Lesley J Woods, Sa A Wang, Doreen Brettler, Mary Andersen, Patricia M Miron, Liberto Pechet, Bruce A Woda, Suyang Hao.
Abstract
Chronic basophilic leukemia is a rare and poorly characterized entity. Only a limited number of cases have been described. Herein, we report a patient who presented with fatigue, weight loss, leukocytosis, persistent prominent basophilia, and mild eosinophilia. The bone marrow showed features characteristic of a myeloproliferative neoplasm with a marked increase in maturing basophils. The basophils exhibited nuclear hypersegmentation, abnormal granulation, and abnormally low CD38 expression. Conventional karyotyping revealed a t(5;12)(q31;p13). ETV6 but not PDGFRB rearrangement was detected by fluorescence in situ hybridization.Entities:
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Year: 2009 PMID： 19427022 DOI： 10.1016/j.humpath.2009.02.011
Source DB: PubMed Journal: Hum Pathol ISSN： 0046-8177 Impact factor: 3.466