| Literature DB >> 19425026 |
Zhaohua Huang1, Mahmoud Reza Jaafari, Francis C Szoka.
Abstract
Extreme makeover of cholesterol: Cholesterol exchange is a major reason for the instability of liposomes in blood. The formation of a covalent hybrid between cholesterol and glycerophosphocholine preserves the bilayer-stabilizing effect of free cholesterol but prevents its transfer from the bilayer. Thus, disterolphospholipids (e.g. 1) are valuable new components for liposome formulation.Entities:
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Year: 2009 PMID: 19425026 PMCID: PMC2773798 DOI: 10.1002/anie.200900111
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN: 1433-7851 Impact factor: 15.336