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Literature DB >> 1942426

Astemizole-induced cardiac conduction disturbances in a child.

J R Tobin¹, T P Doyle, A D Ackerman, J I Brenner.

Abstract

The newly available antihistamine astemizole (Hismanal) has been previously associated with hemodynamically significant cardiac tachydysrhythmias. We describe a 3-year-old girl who developed multiple different cardiac dysrhythmias after an astemizole overdose. No hemodynamic compromise occurred, and the electrocardiogram returned to normal without use of antiarrhythmic agents within 7 hours.

Entities: Chemical Disease Species

Mesh：

Substances：
Astemizole

Year: 1991 PMID： 1942426

Source DB: PubMed Journal: JAMA ISSN： 0098-7484 Impact factor: 56.272

Keyword Cloud
Cited

12 in total

Review 1. Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.

Authors: J Llenas; I Cardelús; A Heredia; F de Mora; R W Gristwood
Journal: Drug Saf Date: 1999 Impact factor: 5.606

Review 2. Cytochrome P450 3A: ontogeny and drug disposition.

Authors: S N de Wildt; G L Kearns; J S Leeder; J N van den Anker
Journal: Clin Pharmacokinet Date: 1999-12 Impact factor: 6.447

3. Antihistamines and the heart.

Authors: D Marquardt
Journal: West J Med Date: 1993-06

Review 4. Comparative tolerability of second generation antihistamines.

Authors: F Horak; U P Stübner
Journal: Drug Saf Date: 1999-05 Impact factor: 5.606

5. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

Authors: Hanna Phan; Matthew L Moeller; Milap C Nahata
Journal: Drugs Date: 2009 Impact factor: 9.546

6. Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands.

Authors: R M Herings; B H Stricker; H G Leufkens; A Bakker; F Sturmans; J Urquhart
Journal: Pharm World Sci Date: 1993-10-15

Astemizole-induced cardiac conduction disturbances in a child.

Review 1. Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.

Review 2. Cytochrome P450 3A: ontogeny and drug disposition.

3. Antihistamines and the heart.

Review 4. Comparative tolerability of second generation antihistamines.

5. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.

6. Public health problems and the rapid estimation of the size of the population at risk. Torsades de pointes and the use of terfenadine and astemizole in The Netherlands.

Review 7. Macrolide antibacterials. Drug interactions of clinical significance.

8. Possible interactions with terfenadine or astemizole.

Review 9. H1-receptor antagonists. Comparative tolerability and safety.

Review 10. Safety and tolerability of treatments for allergic rhinitis in children.