Literature DB >> 19424011

Mechanisms of transplantation tolerance in animals and humans.

Megan Sykes1.   

Abstract

Donor-specific immune tolerance would avoid the toxicities of chronic immunosuppressive therapies while preventing graft rejection. Hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. The mechanisms of tolerance in these trials and the animal studies leading up to them are discussed.

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Mesh：

Year:  2009        PMID： 19424011      PMCID： PMC2720021          DOI： 10.1097/TP.0b013e3181a2a6b8

Source DB:  PubMed          Journal:  Transplantation        ISSN： 0041-1337            Impact factor:   4.939


  27 in total

1.  Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance.

Authors:  B Nikolic; A Khan; M Sykes
Journal:  Biol Blood Marrow Transplant       Date:  2001       Impact factor: 5.742

2.  CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway.

Authors:  H Ito; J Kurtz; J Shaffer; M Sykes
Journal:  J Immunol       Date:  2001-03-01       Impact factor: 5.422

3.  Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells.

Authors:  J Kurtz; H Ito; T Wekerle; J Shaffer; M Sykes
Journal:  Am J Transplant       Date:  2001-11       Impact factor: 8.086

4.  Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.

Authors:  T Wekerle; J Kurtz; H Ito; J V Ronquillo; V Dong; G Zhao; J Shaffer; M H Sayegh; M Sykes
Journal:  Nat Med       Date:  2000-04       Impact factor: 53.440

5.  CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.

Authors:  Josef Kurtz; Forum Raval; Casey Vallot; Jayden Der; Megan Sykes
Journal:  Blood       Date:  2009-01-29       Impact factor: 22.113

6.  Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.

Authors:  Markus Y Mapara; Yong-Mi Kim; Sheng-Ping Wang; Roderick Bronson; David H Sachs; Megan Sykes
Journal:  Blood       Date:  2002-09-01       Impact factor: 22.113

7.  Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.

Authors:  Thomas R Spitzer; Steven L McAfee; Bimalangshu R Dey; Christine Colby; James Hope; Howard Grossberg; Frederic Preffer; Juanita Shaffer; Stephen I Alexander; David H Sachs; Megan Sykes
Journal:  Transplantation       Date:  2003-05-27       Impact factor: 4.939

8.  Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L.

Authors:  Yasuo Takeuchi; Hiroshi Ito; Josef Kurtz; Thomas Wekerle; Leon Ho; Megan Sykes
Journal:  Am J Transplant       Date:  2004-01       Impact factor: 8.086

9.  Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism.

Authors:  Markus Y Mapara; Yong-Mi Kim; Julie Marx; Megan Sykes
Journal:  Transplantation       Date:  2003-07-27       Impact factor: 4.939

10.  Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation.

Authors:  Bimalangshu R Dey; Steven McAfee; Christine Colby; Robert Sackstein; Susan Saidman; Nancy Tarbell; David H Sachs; Megan Sykes; Thomas R Spitzer
Journal:  Biol Blood Marrow Transplant       Date:  2003-05       Impact factor: 5.742
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  6 in total

1.  Mechanisms of tolerance to parental parathyroid tissue when combined with human allogeneic thymus transplantation.

Authors:  Ivan K Chinn; John A Olson; Michael A Skinner; Elizabeth A McCarthy; Stephanie E Gupton; Dong-Feng Chen; Francisco A Bonilla; Robert L Roberts; Maria G Kanariou; Blythe H Devlin; M Louise Markert
Journal:  J Allergy Clin Immunol       Date:  2010-09-15       Impact factor: 10.793

Review 2.  Hematopoietic stem cells and solid organ transplantation.

Authors:  Reza Elahimehr; Andrew T Scheinok; Dianne B McKay
Journal:  Transplant Rev (Orlando)       Date:  2016-08-03       Impact factor: 3.943

Review 3.  Tolerance after solid organ and hematopoietic cell transplantation.

Authors:  Paul Szabolcs; William J Burlingham; Angus W Thomson
Journal:  Biol Blood Marrow Transplant       Date:  2012-01       Impact factor: 5.742

4.  Macrochimerism in Intestinal Transplantation: Association With Lower Rejection Rates and Multivisceral Transplants, Without GVHD.

Authors:  J Zuber; S Rosen; B Shonts; B Sprangers; T M Savage; S Richman; S Yang; S P Lau; S DeWolf; D Farber; G Vlad; E Zorn; W Wong; J Emond; B Levin; M Martinez; T Kato; M Sykes
Journal:  Am J Transplant       Date:  2015-05-18       Impact factor: 8.086

5.  Splenocyte Infusion and Whole-Body Irradiation for Induction of Peripheral Tolerance in Porcine Lung Transplantation: Modifications of the Preconditioning Regime for Improved Clinical Feasibility.

Authors:  Katharina Jansson; Karla Dreckmann; Wiebke Sommer; Murat Avsar; Jawad Salman; Thierry Siemeni; Ann-Kathrin Knöfel; Linda Pauksch; Jens Gottlieb; Jörg Frühauf; Martin Werner; Danny Jonigk; Martin Strüber; Axel Haverich; Gregor Warnecke
Journal:  Transplant Direct       Date:  2017-06-06

6.  Notch-Expanded Murine Hematopoietic Stem and Progenitor Cells Mitigate Death from Lethal Radiation and Convey Immune Tolerance in Mismatched Recipients.

Authors:  Filippo Milano; Fabiola Merriam; Ian Nicoud; Jianqiang Li; Ted A Gooley; Shelly Heimfeld; Suzan Imren; Colleen Delaney
Journal:  Stem Cells Transl Med       Date:  2016-09-13       Impact factor: 6.940
  6 in total

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