Literature DB >> 19423348

Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

Amanda C Kasper1, Eui Jung Moon, Xiangqian Hu, Yongho Park, Ceshea M Wooten, Hyoungsu Kim, Weitao Yang, Mark W Dewhirst, Jiyong Hong.   

Abstract

We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

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Year:  2009        PMID： 19423348      PMCID： PMC2709708          DOI： 10.1016/j.bmcl.2009.04.071

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  31 in total

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  9 in total

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