| Literature DB >> 19423341 |
Jiquan Zhang1, Jianta Wang, Haoshu Wu, Yaoyao He, Gaofeng Zhu, Xing Cui, Lei Tang.
Abstract
A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway.Entities:
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Year: 2009 PMID： 19423341 DOI： 10.1016/j.bmcl.2009.04.050
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823