| Literature DB >> 19423311 |
D B da Silva1, E C O Tulli, G C G Militão, L V Costa-Lotufo, C Pessoa, M O de Moraes, S Albuquerque, J M de Siqueira.
Abstract
The alkaloid extract and five alkaloids isolated from subterranean stem bark of Duguetia furfuracea (Annonaceae) were investigated for the following activities: antitumoral, trypanocidal and leishmanicidal. Dicentrinone showed weak cytotoxicity, but it had the strongest leishmanicidal activity (IC(50) 0.01 microM). Duguetine and duguetine beta-N-oxide caused considerable antitumoral activity in every cell lines evaluated, although duguetine was more active against trypomastigote forms (IC(50) 9.32 microM) than other alkaloids tested.Entities:
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Year: 2009 PMID： 19423311 DOI： 10.1016/j.phymed.2009.03.019
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340