Literature DB >> 19423195

Synthesis of some novel bioactive 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones via efficient cross-Claisen condensation.

R Venkat Ragavan1, V Vijayakumar, N Suchetha Kumari.   

Abstract

alpha-Oxy/thio substituted-beta-keto esters were synthesized through an efficient cross-Claisen condensation of aryl oxy/thio acetic acid ethyl esters with acid chlorides, then it is converted in situ into 4-oxy/thio substituted-1H-pyrazol-5(4H)-ones by the addition of hydrazine or hydrazine derivatives and screened for their antibacterial, antifungal activities.

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Year:  2009        PMID： 19423195     DOI： 10.1016/j.ejmech.2009.04.010

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  26 in total

1.  5-Ethyl-4-methyl-1H-pyrazol-3(2H)-one.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-15

2.  tert-Butyl 4-{[5-(4-chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]carbon-yl}piperazine-1-carboxyl-ate.

Authors:  R Venkat Ragavan; V Vijayakumar; S Sarveswari; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-30

3.  Ethyl 2-[5-(4-chloro-phen-yl)-1-(4-fluoro-phen-yl)-1H-pyrazol-3-yl]-4-methyl-thia-zole-5-carboxyl-ate.

Authors:  Wan-Sin Loh; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-23

4.  5-Cyclo-hexyl-4-methyl-1H-pyrazol-3(2H)-one monohydrate.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-09

5.  4-Methyl-5-phenyl-1H-pyrazol-3(2H)-one.

Authors:  Wan-Sin Loh; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-12-18

6.  5-Pentyl-4-phenyl-sulfonyl-1H-pyrazol-3-ol.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-29

7.  3-Ethyl-4-phen-oxy-1-(2,2,2-trifluoro-eth-yl)-1H-pyrazol-5-ol.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-07-07

8.  4,5,6,7,8,9-Hexahydro-2H-cyclo-octa[c]pyrazol-1-ium-3-olate.

Authors:  Hoong-Kun Fun; Chin Sing Yeap; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-31

9.  1,3-Dimethyl-4-phenyl-sulfanyl-1H-pyrazol-5-ol.

Authors:  Tara Shahani; Hoong-Kun Fun; R Venkat Ragavan; V Vijayakumar; S Sarveswari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-02-16

10.  Microwave assisted synthesis of novel pyrazolone derivatives attached to a pyrimidine moiety and evaluation of their anti-inflammatory, analgesic and antipyretic activities.

Authors:  Rishikesh V Antre; A Cendilkumar; Divakar Goli; Ganesh S Andhale; Rajesh J Oswal
Journal:  Saudi Pharm J       Date:  2011-06-25       Impact factor: 4.330
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