OBJECTIVE: To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men. DESIGN: Prospective. SETTING: University hospital. PATIENT(S): Forty-two obese fertile and 80 obese infertile oligozoospermic men (body mass index [BMI] >30). INTERVENTION(S): The BMI calculation, semen analysis, and serum FSH, LH, T, E(2), PRL, and leptin estimation. MAIN OUTCOME MEASURE(S): Semen and hormonal profiles. RESULT(S): Obese oligozoospermic patients had significant increase in mean BMI, serum FSH, LH, E(2), PRL, and leptin compared with obese fertile controls. The BMI had significant positive correlation with abnormal sperm morphology, LH, serum leptin and significant negative correlation with sperm concentration, sperm motility, serum T. Serum leptin demonstrated significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T. CONCLUSION(S): Serum leptin mediates a link between obesity and male infertility. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men. DESIGN: Prospective. SETTING: University hospital. PATIENT(S): Forty-two obese fertile and 80 obese infertile oligozoospermicmen (body mass index [BMI] >30). INTERVENTION(S): The BMI calculation, semen analysis, and serum FSH, LH, T, E(2), PRL, and leptin estimation. MAIN OUTCOME MEASURE(S): Semen and hormonal profiles. RESULT(S): Obese oligozoospermic patients had significant increase in mean BMI, serum FSH, LH, E(2), PRL, and leptin compared with obese fertile controls. The BMI had significant positive correlation with abnormal sperm morphology, LH, serum leptin and significant negative correlation with sperm concentration, sperm motility, serum T. Serum leptin demonstrated significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T. CONCLUSION(S): Serum leptin mediates a link between obesity and male infertility. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Jianhua Guo; Yang Zhao; Weiying Huang; Wei Hu; Jianjun Gu; Chuhong Chen; Juan Zhou; Yubing Peng; Min Gong; Zhong Wang Journal: Int J Clin Exp Med Date: 2014-10-15
Authors: Manon Garcia; Laura Thirouard; Mélusine Monrose; Hélène Holota; Angélique De Haze; Françoise Caira; Claude Beaudoin; David H Volle Journal: Cell Mol Life Sci Date: 2019-08-12 Impact factor: 9.261
Authors: N Sermondade; C Faure; L Fezeu; A G Shayeb; J P Bonde; T K Jensen; M Van Wely; J Cao; A C Martini; M Eskandar; J E Chavarro; S Koloszar; J M Twigt; C H Ramlau-Hansen; E Borges; F Lotti; R P M Steegers-Theunissen; B Zorn; A J Polotsky; S La Vignera; B Eskenazi; K Tremellen; E V Magnusdottir; I Fejes; S Hercberg; R Lévy; S Czernichow Journal: Hum Reprod Update Date: 2012-12-12 Impact factor: 15.610