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Literature DB >> 19422008

Engineered two-helix small proteins for molecular recognition.

Jack M Webster¹, Rong Zhang, Sanjiv S Gambhir, Zhen Cheng, Faisal A Syud.

Abstract

Less is more: By starting with a high-affinity HER2-binding 3-helix affibody molecule, we successfully developed 2-helix small protein binders with 5 nM affinities by using a combination of several different strategies. Our efforts clearly suggest that 2-helix small proteins against important tumor targets can be obtained by rational protein design and engineering.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19422008 DOI： 10.1002/cbic.200900062

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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Cited

18 in total

Review 1. Protein scaffold-based molecular probes for cancer molecular imaging.

Authors: Zheng Miao; Jelena Levi; Zhen Cheng
Journal: Amino Acids Date: 2010-02-21 Impact factor: 3.520

2. PET imaging of HER-2-positive tumours.

Authors: Laura Gilardi; Giovanni Paganelli
Journal: Eur J Nucl Med Mol Imaging Date: 2011-11 Impact factor: 9.236

3. Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy.

Authors: James W Checco; Geoffrey A Eddinger; Nicholas J Rettko; Alexander R Chartier; Samuel H Gellman
Journal: ACS Chem Biol Date: 2020-07-14 Impact factor: 5.100

4. In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.

Authors: Gang Ren; Jack M Webster; Zhe Liu; Rong Zhang; Zheng Miao; Hongguang Liu; Sanjiv S Gambhir; Faisal A Syud; Zhen Cheng
Journal: Amino Acids Date: 2011-10-08 Impact factor: 3.520

5. Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold.

Authors: James W Checco; Dale F Kreitler; Nicole C Thomas; David G Belair; Nicholas J Rettko; William L Murphy; Katrina T Forest; Samuel H Gellman
Journal: Proc Natl Acad Sci U S A Date: 2015-03-30 Impact factor: 11.205

6. Iterative Nonproteinogenic Residue Incorporation Yields α/β-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF.

Authors: James W Checco; Samuel H Gellman
Journal: Chembiochem Date: 2017-01-09 Impact factor: 3.164

Engineered two-helix small proteins for molecular recognition.

Review 1. Protein scaffold-based molecular probes for cancer molecular imaging.

2. PET imaging of HER-2-positive tumours.

3. Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy.

4. In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.

5. Targeting diverse protein-protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold.

6. Iterative Nonproteinogenic Residue Incorporation Yields α/β-Peptides with a Helix-Loop-Helix Tertiary Structure and High Affinity for VEGF.

7. Alternative Non-Antibody Protein Scaffolds for Molecular Imaging of Cancer.

8. A novel 18F-labeled two-helix scaffold protein for PET imaging of HER2-positive tumor.

9. HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug.

10. A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.