BACKGROUND: Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important role in fat metabolism linking obesity and the metabolic syndrome. Increasing A-FABP plasma levels were observed during greatest weight loss after bariatric surgery suggesting that A-FABP may indicate changes in fat mass in dynamic situations. AIM OF THE STUDY: As there are no data on weight gain, we investigated the effect of refeeding anorexic patients on body composition and A-FABP plasma levels. METHODS: Parameters of glucose and lipid metabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in 16 female patients with anorexia nervosa during inpatient weight restoration. Body composition was determined by multifrequency body impedance analysis. RESULTS: After 28 days, fat mass increased from 4.4 +/- 2.5 kg at baseline to 5.5 +/- 2.2 kg (P < 0.01), constituting 40% of total weight gain. Conversely, A-FABP concentrations decreased from 32.56 +/- 35.59 ng/ml at baseline to 21.27 +/- 13.68 ng/ml (P < 0.05), which corresponds to a significant decrease in the proportion of A-FABP per kilogram fat mass from 7.86 +/- 5.23 to 4.09 +/- 2.12 ng/ml/kg (P </= 0.001). Variation in A-FABP plasma concentration was predictive for changes in total cholesterol levels (adjusted r (2) = 0.239; P < or = 0.05), but not for gain in weight, fat mass, or percent body fat. CONCLUSION: The present results indicate that variation in A-FABP plasma levels reflect alterations in nutritional status in patients with anorexia nervosa.
BACKGROUND:Adipocyte fatty acid binding protein (A-FABP) has been suggested to play an important role in fat metabolism linking obesity and the metabolic syndrome. Increasing A-FABP plasma levels were observed during greatest weight loss after bariatric surgery suggesting that A-FABP may indicate changes in fat mass in dynamic situations. AIM OF THE STUDY: As there are no data on weight gain, we investigated the effect of refeeding anorexic patients on body composition and A-FABP plasma levels. METHODS: Parameters of glucose and lipid metabolism as well as plasma levels of leptin and A-FABP were prospectively assessed in 16 female patients with anorexia nervosa during inpatient weight restoration. Body composition was determined by multifrequency body impedance analysis. RESULTS: After 28 days, fat mass increased from 4.4 +/- 2.5 kg at baseline to 5.5 +/- 2.2 kg (P < 0.01), constituting 40% of total weight gain. Conversely, A-FABP concentrations decreased from 32.56 +/- 35.59 ng/ml at baseline to 21.27 +/- 13.68 ng/ml (P < 0.05), which corresponds to a significant decrease in the proportion of A-FABP per kilogram fat mass from 7.86 +/- 5.23 to 4.09 +/- 2.12 ng/ml/kg (P </= 0.001). Variation in A-FABP plasma concentration was predictive for changes in total cholesterol levels (adjusted r (2) = 0.239; P < or = 0.05), but not for gain in weight, fat mass, or percent body fat. CONCLUSION: The present results indicate that variation in A-FABP plasma levels reflect alterations in nutritional status in patients with anorexia nervosa.
Authors: G Gross; J D Russell; P J Beumont; S W Touyz; P Roach; A Aslani; R D Hansen; B J Allen Journal: Ann N Y Acad Sci Date: 2000-05 Impact factor: 5.691
Authors: C Davis; D K Katzman; S Kaptein; C Kirsh; H Brewer; K Kalmbach; M P Olmsted; D B Woodside; A S Kaplan Journal: Compr Psychiatry Date: 1997 Nov-Dec Impact factor: 3.735