| Literature DB >> 1942009 |
F J Novembre1, V M Hirsch, H M McClure, P R Johnson.
Abstract
The molecular diversity of SIVsmm/PBj proviral genomes in tissues of an infected macaque was analyzed. Molecular clones derived directly from intestinal tissue DNA were heterogenous, and contained LTRs with one or two NF-kB binding sites. LTRs with one NF-kB site predominated (approximately 75%). Virions derived from biologically active chimeric DNA clones with one or two NF-kB sites did not induce the acute death syndrome characteristic of PBj infection. These results suggest that either the duplicated NF-kB site acts in concert with other important viral determinants, or plays no role in producing the PBj syndrome.Entities:
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Year: 1991 PMID： 1942009
Source DB: PubMed Journal: J Med Primatol ISSN： 0047-2565 Impact factor: 0.667