| Literature DB >> 19419854 |
John Hardy1, Patrick Lewis, Tamas Revesz, Andrew Lees, Coro Paisan-Ruiz.
Abstract
Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.Entities:
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Year: 2009 PMID： 19419854 DOI： 10.1016/j.gde.2009.03.008
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578