| Literature DB >> 1941852 |
M F Healsmith1, J Berth-Jones, A Fletcher, R A Graham-Brown.
Abstract
We report a series of 11 basal cell carcinomas of various types treated with nine intra-lesional injections of 1.5 million units of interferon alpha-2b. The diagnosis was confirmed histologically in each case. After 3 months' follow-up six tumours had resolved both clinically and histologically. In three cases the tumour size was reduced. One tumour grew larger. Side effects were well tolerated except by one subject who was withdrawn. Those cases which responded have now been followed-up for between 12 and 26 months with no clinical or histological evidence of tumour recurrence. This is the longest period of follow-up so far reported for this novel treatment. The results are encouraging and, if maintained in future series, may indicate a useful role for interferon alpha in the management of this common cutaneous malignancy.Entities:
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Year: 1991 PMID： 1941852 PMCID： PMC1293410 DOI： 10.1177/014107689108400907
Source DB: PubMed Journal: J R Soc Med ISSN： 0141-0768 Impact factor: 18.000