Preparation of the endometrium for ablation with a single dose of leuprolide acetate depot.

Several reports describe enhancing the efficacy of laser or resectoscopic endometrial ablation procedures by preparing the endometrium with danazol or progestin therapy. Because gonadotropin releasing hormone agonists have been found to inhibit the thickness and development of the endometrial lining, preparation of the endometrium for resectoscopic ablation was attempted on eight women using a single injection of 7.5 mg of leuprolide acetate depot. When the ablation was performed, one month after the injection of the medication, which had occurred on day 20-24 of the prior menstrual cycle, the endometrium was thinned in all the patients, with inactive glands, reduced vascularity and atrophic stroma.