PURPOSE OF REVIEW: It has recently been recognized that cholesterol homeostasis is fundamentally important for appropriate insulin secretory function of beta-cells in the pancreas. This review summarizes recent advances in understanding the relationship between beta-cell cholesterol metabolism and beta-cell function. RECENT FINDINGS: The accumulation of cholesterol in beta-cells causes perturbations in glucose metabolism, reduces insulin secretion and can be associated with a diabetic phenotype. Cholesterol is also a key determinant of beta-cell membrane organization and cell survival. The ATP-binding cassette transporter A1, which effluxes cholesterol to lipid-free/lipid-poor apolipoprotein A-I, the principal apolipoprotein in HDLs, is crucial for maintaining beta-cell cholesterol homeostasis and function. There is also evidence suggesting that different lipoprotein classes have varying effects on beta-cell function and survival. SUMMARY: Cholesterol is important for beta-cell function and survival. It can cause beta-cell loss if allowed to accumulate in the cells in an unregulated manner. The maintenance of beta-cell cholesterol homeostasis, therefore, is important for preventing beta-cell dysfunction, the onset of insulin resistance and the development of type 2 diabetes.
PURPOSE OF REVIEW: It has recently been recognized that cholesterol homeostasis is fundamentally important for appropriate insulin secretory function of beta-cells in the pancreas. This review summarizes recent advances in understanding the relationship between beta-cell cholesterol metabolism and beta-cell function. RECENT FINDINGS: The accumulation of cholesterol in beta-cells causes perturbations in glucose metabolism, reduces insulin secretion and can be associated with a diabetic phenotype. Cholesterol is also a key determinant of beta-cell membrane organization and cell survival. The ATP-binding cassette transporter A1, which effluxes cholesterol to lipid-free/lipid-poor apolipoprotein A-I, the principal apolipoprotein in HDLs, is crucial for maintaining beta-cell cholesterol homeostasis and function. There is also evidence suggesting that different lipoprotein classes have varying effects on beta-cell function and survival. SUMMARY:Cholesterol is important for beta-cell function and survival. It can cause beta-cell loss if allowed to accumulate in the cells in an unregulated manner. The maintenance of beta-cell cholesterol homeostasis, therefore, is important for preventing beta-cell dysfunction, the onset of insulin resistance and the development of type 2 diabetes.
Authors: Stefan Kubicek; Joshua C Gilbert; Dina Fomina-Yadlin; Alexander D Gitlin; Yuan Yuan; Florence F Wagner; Edward B Holson; Tuoping Luo; Timothy A Lewis; Bradley Taylor; Supriya Gupta; Alykhan F Shamji; Bridget K Wagner; Paul A Clemons; Stuart L Schreiber Journal: Proc Natl Acad Sci U S A Date: 2012-03-20 Impact factor: 11.205
Authors: Jingzhong Ding; Lindsay M Reynolds; Tanja Zeller; Christian Müller; Kurt Lohman; Barbara J Nicklas; Stephen B Kritchevsky; Zhiqing Huang; Alberto de la Fuente; Nicola Soranzo; Robert E Settlage; Chia-Chi Chuang; Timothy Howard; Ning Xu; Mark O Goodarzi; Y-D Ida Chen; Jerome I Rotter; David S Siscovick; John S Parks; Susan Murphy; David R Jacobs; Wendy Post; Russell P Tracy; Philipp S Wild; Stefan Blankenberg; Ina Hoeschele; David Herrington; Charles E McCall; Yongmei Liu Journal: Diabetes Date: 2015-07-07 Impact factor: 9.461
Authors: Geertruida J van Woudenbergh; Adriana J van Ballegooijen; Anneleen Kuijsten; Eric J G Sijbrands; Frank J A van Rooij; Johanna M Geleijnse; Albert Hofman; Jacqueline C M Witteman; Edith J M Feskens Journal: Diabetes Care Date: 2009-08-12 Impact factor: 19.112