Literature DB >> 19416759

Drug discovery chemistry: a primer for the non-specialist.

Allan M Jordan1, Stephen D Roughley.   

Abstract

Like all scientific disciplines, drug discovery chemistry is rife with terminology and methodology that can seem intractable to those outside the sphere of synthetic chemistry. Derived from a successful in-house workshop, this Foundation Review aims to demystify some of this inherent terminology, providing the non-specialist with a general insight into the nomenclature, terminology and workflow of medicinal chemists within the pharmaceutical industry.

Mesh：

Year:  2009        PMID： 19416759     DOI： 10.1016/j.drudis.2009.04.005

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  7 in total

Review 1.  Rethinking drug design in the artificial intelligence era.

Authors:  Petra Schneider; W Patrick Walters; Alleyn T Plowright; Norman Sieroka; Jennifer Listgarten; Robert A Goodnow; Jasmin Fisher; Johanna M Jansen; José S Duca; Thomas S Rush; Matthias Zentgraf; John Edward Hill; Elizabeth Krutoholow; Matthias Kohler; Jeff Blaney; Kimito Funatsu; Chris Luebkemann; Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2019-12-04       Impact factor: 84.694

2.  Silyl-mediated photoredox-catalyzed Giese reaction: addition of non-activated alkyl bromides.

Authors:  Abdellatif ElMarrouni; Casey B Ritts; Jaume Balsells
Journal:  Chem Sci       Date:  2018-07-11       Impact factor: 9.825

3.  Synthesis, optical imaging, and absorption spectroscopy data for 179072 metal oxides.

Authors:  Helge S Stein; Edwin Soedarmadji; Paul F Newhouse; John M Gregoire
Journal:  Sci Data       Date:  2019-03-27       Impact factor: 6.444

4.  C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors.

Authors:  Vigneshwaran Namasivayam; Katja Silbermann; Michael Wiese; Jens Pahnke; Sven Marcel Stefan
Journal:  J Med Chem       Date:  2021-03-16       Impact factor: 7.446

5.  A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors.

Authors:  Sven Marcel Stefan; Patric Jan Jansson; Jens Pahnke; Vigneshwaran Namasivayam
Journal:  Sci Data       Date:  2022-07-26       Impact factor: 8.501

6.  Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA).

Authors:  Vigneshwaran Namasivayam; Katja Silbermann; Jens Pahnke; Michael Wiese; Sven Marcel Stefan
Journal:  Comput Struct Biotechnol J       Date:  2021-05-10       Impact factor: 7.271

7.  Aromatic Rings Commonly Used in Medicinal Chemistry: Force Fields Comparison and Interactions With Water Toward the Design of New Chemical Entities.

Authors:  Marcelo D Polêto; Victor H Rusu; Bruno I Grisci; Marcio Dorn; Roberto D Lins; Hugo Verli
Journal:  Front Pharmacol       Date:  2018-04-24       Impact factor: 5.810
  7 in total

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