| Literature DB >> 19416709 |
Mark P Mattson1, Stuart Maudsley.
Abstract
Excessive activation of the AT(1A) receptor (AT(1A)R) by angiotensin II (Ang II) is implicated in the age-related development of hypertension, diabetes, and kidney disease. AT(1A)R-deficient mice live longer and have lower levels of oxidative stress than wild-type mice (Benigni et al., 2009), suggesting a role for AT(1A)R signaling in the aging process.Entities:
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Year: 2009 PMID： 19416709 PMCID： PMC2697617 DOI： 10.1016/j.cmet.2009.04.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287