Literature DB >> 19416212

Relaxin as a protective substance in the preserving solution for liver transplantation: spectrophotometric in vivo imaging of local oxygen supply in an isolated perfused rat liver model.

Markus U Boehnert1, Franz Paul Armbruster, Heidegard Hilbig.   

Abstract

Ischemia reperfusion injury (IRI) is a problem in organ transplantation. Relaxin is known to have a protective effect against liver injury caused by IRI. Using a model of isolated perfused rat liver, the local oxygen supply in liver tissue was investigated by spectrophotometric in vivo imaging and compared to the protective effect of relaxin shown by immunohistochemical measurement of myeloperoxidase and malonyldialdehyde activities as determinants of oxidative stress. In relaxin-treated liver tissue, spectrophotometry showed a better oxygen supply and decreased myeloperoxidase and malonyldialdehyde activities. Our data suggest that relaxin can influence the oxygen distribution in liver tissue and reduce cell damage caused by IRI.

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Year:  2009        PMID： 19416212     DOI： 10.1111/j.1749-6632.2008.03804.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  7 in total

Review 1.  Renal impairment and worsening of renal function in acute heart failure: can new therapies help? The potential role of serelaxin.

Authors:  Roland E Schmieder; Veselin Mitrovic; Christian Hengstenberg
Journal:  Clin Res Cardiol       Date:  2015-03-19       Impact factor: 5.460

Review 2.  International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

Authors:  Michelle L Halls; Ross A D Bathgate; Steve W Sutton; Thomas B Dschietzig; Roger J Summers
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

Review 3.  Serelaxin for the treatment of acute heart failure: a review with a focus on end-organ protection.

Authors:  Javier Díez; Luis M Ruilope
Journal:  Eur Heart J Cardiovasc Pharmacother       Date:  2015-11-26

Review 4.  Relaxin Positively Influences Ischemia-Reperfusion Injury in Solid Organ Transplantation: A Comprehensive Review.

Authors:  Lina Jakubauskiene; Matas Jakubauskas; Bettina Leber; Kestutis Strupas; Philipp Stiegler; Peter Schemmer
Journal:  Int J Mol Sci       Date:  2020-01-17       Impact factor: 5.923

5.  Custodiol® Supplemented with Synthetic Human Relaxin Decreases Ischemia-Reperfusion Injury after Porcine Kidney Transplantation.

Authors:  Augustinas Bausys; Juste Maneikyte; Bettina Leber; Jennifer Weber; Nicole Feldbacher; Kestutis Strupas; Thomas Bernd Dschietzig; Peter Schemmer; Philipp Stiegler
Journal:  Int J Mol Sci       Date:  2021-10-22       Impact factor: 5.923

Review 6.  Serelaxin: a novel therapy for acute heart failure with a range of hemodynamic and non-hemodynamic actions.

Authors:  Javier Díez
Journal:  Am J Cardiovasc Drugs       Date:  2014-08       Impact factor: 3.571

Review 7.  Adipokines and Inflammation: Focus on Cardiovascular Diseases.

Authors:  Sandra Feijóo-Bandín; Alana Aragón-Herrera; Sandra Moraña-Fernández; Laura Anido-Varela; Estefanía Tarazón; Esther Roselló-Lletí; Manuel Portolés; Isabel Moscoso; Oreste Gualillo; José Ramón González-Juanatey; Francisca Lago
Journal:  Int J Mol Sci       Date:  2020-10-18       Impact factor: 5.923
  7 in total

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