Literature DB >> 19416209

Role of relaxin in maternal systemic and renal vascular adaptations during gestation.

Jonathan T McGuane1, Julianna E Debrah, Dan O Debrah, J Peter Rubin, Mark Segal, Sanjeev G Shroff, Kirk P Conrad.   

Abstract

In this paper, the hemodynamic changes of normal pregnancy are reviewed and the underlying hormonal and molecular mechanisms are discussed. Among other findings related to these phenomena, our previous work has demonstrated the importance of relaxin in systemic and renal vascular as well as osmoregulatory changes during gestation. These findings are summarized, and new concepts related to the function of relaxin in blood vessels are presented. Finally, work in progress is briefly outlined.

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Year:  2009        PMID: 19416209     DOI: 10.1111/j.1749-6632.2009.03829.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  14 in total

Review 1.  Pregnancy and the endocrine regulation of the baroreceptor reflex.

Authors:  Virginia L Brooks; Roger A L Dampney; Cheryl M Heesch
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-05-26       Impact factor: 3.619

2.  Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization.

Authors:  Valerie L Baker; Morton B Brown; Barbara Luke; Kirk P Conrad
Journal:  Fertil Steril       Date:  2015-01-28       Impact factor: 7.329

3.  GPCRs as potential therapeutic targets in preeclampsia.

Authors:  Jt McGuane; Kp Conrad
Journal:  Drug Discov Today Dis Models       Date:  2012-07-12

Review 4.  Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia.

Authors:  Kirk P Conrad
Journal:  Semin Nephrol       Date:  2011-01       Impact factor: 5.299

5.  Chronic vasodilation produces plasma volume expansion and hemodilution in rats: consequences of decreased effective arterial blood volume.

Authors:  Andrea Fekete; Jennifer M Sasser; Chris Baylis
Journal:  Am J Physiol Renal Physiol       Date:  2010-10-27

6.  Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.

Authors:  Jonathan T McGuane; Julianna E Debrah; Laura Sautina; Yagna P R Jarajapu; Jacqueline Novak; J Peter Rubin; Maria B Grant; Mark Segal; Kirk P Conrad
Journal:  Endocrinology       Date:  2011-05-10       Impact factor: 4.736

Review 7.  Unveiling the vasodilatory actions and mechanisms of relaxin.

Authors:  Kirk P Conrad
Journal:  Hypertension       Date:  2010-05-24       Impact factor: 10.190

8.  The ouabain-binding site of the α2 isoform of Na,K-ATPase plays a role in blood pressure regulation during pregnancy.

Authors:  Naomi Oshiro; Iva Dostanic-Larson; Jon C Neumann; Jerry B Lingrel
Journal:  Am J Hypertens       Date:  2010-09-09       Impact factor: 2.689

Review 9.  Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia.

Authors:  Omar C Logue; Eric M George; Gene L Bidwell
Journal:  Clin Sci (Lond)       Date:  2016-08-01       Impact factor: 6.124

Review 10.  Pregnancy and cardiovascular disease.

Authors:  Karishma P Ramlakhan; Mark R Johnson; Jolien W Roos-Hesselink
Journal:  Nat Rev Cardiol       Date:  2020-06-09       Impact factor: 32.419

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