Literature DB >> 19415708

Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.

Shengying Li1, Yojiro Anzai, Kenji Kinoshita, Fumio Kato, David H Sherman.   

Abstract

Mg motors: We characterized the in vitro function of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin antibiotics. Each enzyme was confirmed to be an S-adenosyl-L-methionine (SAM)-dependent deoxysugar methyltransferase. Their optimal activities require the presence of Mg(2+). With the reconstituted in vitro assays, the order of mycinamicin VI-->III-->IV in the post-PKS (polyketide synthase) tailoring pathway of mycinamicin was unambiguously determined.

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Year:  2009        PMID： 19415708      PMCID： PMC2861363          DOI： 10.1002/cbic.200900088

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  21 in total

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Journal:  Nat Prod Rep       Date:  1999-06       Impact factor: 13.423

2.  Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases.

Authors:  C Zubieta; X Z He; R A Dixon; J P Noel
Journal:  Nat Struct Biol       Date:  2001-03

3.  Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.

Authors:  Yojiro Anzai; Natsumi Saito; Michiyasu Tanaka; Kenji Kinoshita; Yasumasa Koyama; Fumio Kato
Journal:  FEMS Microbiol Lett       Date:  2003-01-21       Impact factor: 2.742

4.  Biosynthesis of mycinamicins by a blocked mutant of Micromonospora griseorubida.

Authors:  H Suzuki; S Takenaka; K Kinoshita; T Morohoshi
Journal:  J Antibiot (Tokyo)       Date:  1990-11       Impact factor: 2.649

5.  Mycinamicins, new macrolide antibiotics. XII. Isolation and structural elucidation of mycinamicins X and XI.

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Journal:  J Antibiot (Tokyo)       Date:  1991-11       Impact factor: 2.649

6.  Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus.

Authors:  I Aguirrezabalaga; C Olano; N Allende; L Rodriguez; A F Braña; C Méndez; J A Salas
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

7.  Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties.

Authors:  S Satoi; N Muto; M Hayashi; T Fujii; M Otani
Journal:  J Antibiot (Tokyo)       Date:  1980-04       Impact factor: 2.649

8.  The targeted inactivation of polyketide synthase mycAV in the mycinamicin producer, Micromonospora griseorubida, and a complementation study.

Authors:  Yojiro Anzai; Yuka Ishii; Yukie Yoda; Kenji Kinoshita; Fumio Kato
Journal:  FEMS Microbiol Lett       Date:  2004-09-15       Impact factor: 2.742

9.  Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae.

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Journal:  J Biol Chem       Date:  1988-10-25       Impact factor: 5.157

10.  Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.

Authors:  A J Kreuzman; J R Turner; W K Yeh
Journal:  J Biol Chem       Date:  1988-10-25       Impact factor: 5.157
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  10 in total

1.  A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

Authors:  David L Akey; Shengying Li; Jamie R Konwerski; Laura A Confer; Steffen M Bernard; Yojiro Anzai; Fumio Kato; David H Sherman; Janet L Smith
Journal:  J Mol Biol       Date:  2011-08-23       Impact factor: 5.469

2.  Chemoenzymatic Total Synthesis and Structural Diversification of Tylactone-Based Macrolide Antibiotics through Late-Stage Polyketide Assembly, Tailoring, and C-H Functionalization.

Authors:  Andrew N Lowell; Matthew D DeMars; Samuel T Slocum; Fengan Yu; Krithika Anand; Joseph A Chemler; Nisha Korakavi; Jennifer K Priessnitz; Sung Ryeol Park; Aaron A Koch; Pamela J Schultz; David H Sherman
Journal:  J Am Chem Soc       Date:  2017-06-05       Impact factor: 15.419

Review 3.  Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.

Authors:  Nikhat Parveen; Kenneth A Cornell
Journal:  Mol Microbiol       Date:  2010-11-18       Impact factor: 3.501

4.  Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.

Authors:  Steffen M Bernard; David L Akey; Ashootosh Tripathi; Sung Ryeol Park; Jamie R Konwerski; Yojiro Anzai; Shengying Li; Fumio Kato; David H Sherman; Janet L Smith
Journal:  ACS Chem Biol       Date:  2015-02-26       Impact factor: 5.100

5.  Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin.

Authors:  Yojiro Anzai; Shu-ichi Tsukada; Ayami Sakai; Ryohei Masuda; Chie Harada; Ayaka Domeki; Shengying Li; Kenji Kinoshita; David H Sherman; Fumio Kato
Journal:  Antimicrob Agents Chemother       Date:  2012-04-30       Impact factor: 5.191

6.  Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK.

Authors:  Hak Joong Kim; Jess A White-Phillip; Yasushi Ogasawara; Nara Shin; Eta A Isiorho; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2010-03-10       Impact factor: 15.419

7.  Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.

Authors:  Fumitaka Kudo; Yasunori Matsuura; Takaaki Hayashi; Masayuki Fukushima; Tadashi Eguchi
Journal:  J Antibiot (Tokyo)       Date:  2016-04-13       Impact factor: 2.649

8.  Function of the loading module in CorI and of the O-methyltransferase CorH in vinyl carbamate biosynthesis of the antibiotic corallopyronin A.

Authors:  Till F Schäberle; Mahsa Mir Mohseni; Friederike Lohr; Alexander Schmitz; Gabriele M König
Journal:  Antimicrob Agents Chemother       Date:  2013-11-25       Impact factor: 5.191

9.  In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.

Authors:  Alan J Marsh; Orla O'Sullivan; R Paul Ross; Paul D Cotter; Colin Hill
Journal:  BMC Genomics       Date:  2010-11-30       Impact factor: 3.969

10.  Genome mining for radical SAM protein determinants reveals multiple sactibiotic-like gene clusters.

Authors:  Kiera Murphy; Orla O'Sullivan; Mary C Rea; Paul D Cotter; R Paul Ross; Colin Hill
Journal:  PLoS One       Date:  2011-07-08       Impact factor: 3.240
  10 in total

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