Kui-Ran Dong1, Shan Zheng, Xianming Xiao. 1. Department of Pediatric Surgery, Children's Hospital of Fudan University, 399 Wang Yuan Road, 201102, Shanghai, People's Republic of China.
Abstract
PURPOSE: To summarize the conservative treatment of neonatal hepatic hemangioma at one institute. PATIENTS AND MATERIALS: Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years. Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed. RESULTS: Initial symptoms were abdominal mass, hepatomegaly, jaundice, and pneumonia. Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency. Ultrasound and CT showed the typical characteristics of the liver hemangioma. There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver. The diameter of a single focus in this group was about 53-99 mm. Four cases of single focus received resection and two received biopsy. Six cases received corticosteroid treatment. The other five cases were kept under observation only. Those with cardiac insufficiency and pneumonia received diuretics and antibiotic treatment. One neonate with cardiac insufficiency and pneumonia had postoperative MODS and died. One patient having multi-focus in the liver gave up the treatment after biopsy. Other patients were followed-up at 5-17 months. Two cases that received total tumor resection did not have recurrence. In those who received conservative therapy, all hemangiomas disappeared within 1 year. CONCLUSION: The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary. Corticosteroid therapy is the widely used therapy. Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma. Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.
PURPOSE: To summarize the conservative treatment of neonatal hepatic hemangioma at one institute. PATIENTS AND MATERIALS: Fifteen cases of neonatal hepatic hemangioma were managed in our hospital during the previous 5 years. Initial symptoms, combination symptoms, diagnosis, and treatment were analyzed. RESULTS: Initial symptoms were abdominal mass, hepatomegaly, jaundice, and pneumonia. Combination symptoms were multiple skin hemangiomas, pneumonia, and cardiac insufficiency. Ultrasound and CT showed the typical characteristics of the liver hemangioma. There were three types of hepatic hemangioma: nine cases had a single focus, four cases were multiple foci, and two had diffuse changes in the liver. The diameter of a single focus in this group was about 53-99 mm. Four cases of single focus received resection and two received biopsy. Six cases received corticosteroid treatment. The other five cases were kept under observation only. Those with cardiac insufficiency and pneumonia received diuretics and antibiotic treatment. One neonate with cardiac insufficiency and pneumonia had postoperative MODS and died. One patient having multi-focus in the liver gave up the treatment after biopsy. Other patients were followed-up at 5-17 months. Two cases that received total tumor resection did not have recurrence. In those who received conservative therapy, all hemangiomas disappeared within 1 year. CONCLUSION: The diagnosis of hepatic hemangioma can be made from symptomology, ultrasound, and CT; pathologic samples are not necessary. Corticosteroid therapy is the widely used therapy. Proactive therapy for congestive heart failure is helpful for those endangering liver hemangioma. Surgery can increase the risk of complications and is not advised for treatment of neonatal hepatic hemangioma.
Authors: Ilona J Frieden; Anita N Haggstrom; Beth A Drolet; Anthony J Mancini; Sheila Fallon Friedlander; Laurence Boon; Sarah L Chamlin; Eulalia Baselga; Maria C Garzon; Amy J Nopper; Dawn H Siegel; Erin W Mathes; Deborah S Goddard; Joyce Bischoff; Paula E North; Nancy B Esterly Journal: Pediatr Dermatol Date: 2005 Sep-Oct Impact factor: 1.588
Authors: Emily R Christison-Lagay; Patricia E Burrows; Ahmad Alomari; Josée Dubois; Harry P Kozakewich; Tricia S Lane; Harriet J Paltiel; Giannoula Klement; John B Mulliken; Steven J Fishman Journal: J Pediatr Surg Date: 2007-01 Impact factor: 2.545