OBJECTIVE: Craniosynostosis is the premature fusion of the calvarial sutures and is associated with aesthetic impairment and secondary damage to brain growth. Associated neurological injuries can result from increased intracranial pressure (ICP) and abnormal cerebral blood flow (CBF). Arterial spin-labeling (ASL) MRI was used to assess regional CBF in developing rabbits with early-onset coronal suture synostosis (EOCS) and age-matched wild-type controls (WT). METHODS: Rabbits were subjected to ASL MRI at or near 10, 25, or 42 days of age. Differences in regional CBF were assessed using one-way ANOVA. CONCLUSION: CBF was similar in WT and EOCS rabbits with the exception of the peridural surfaces in EOCS rabbits at 25 days of age. A twofold increase in peridural CBF at 25 days of age coincides with a transient increase in ICP. By 42 days of age, CBF in peridural surfaces had decreased.
OBJECTIVE:Craniosynostosis is the premature fusion of the calvarial sutures and is associated with aesthetic impairment and secondary damage to brain growth. Associated neurological injuries can result from increased intracranial pressure (ICP) and abnormal cerebral blood flow (CBF). Arterial spin-labeling (ASL) MRI was used to assess regional CBF in developing rabbits with early-onset coronal suture synostosis (EOCS) and age-matched wild-type controls (WT). METHODS:Rabbits were subjected to ASL MRI at or near 10, 25, or 42 days of age. Differences in regional CBF were assessed using one-way ANOVA. CONCLUSION: CBF was similar in WT and EOCS rabbits with the exception of the peridural surfaces in EOCS rabbits at 25 days of age. A twofold increase in peridural CBF at 25 days of age coincides with a transient increase in ICP. By 42 days of age, CBF in peridural surfaces had decreased.
Authors: M P Mooney; W Fellows-Mayle; H W Losken; J Dechant; A M Burrows; T D Smith; G M Cooper; I Pollack; M I Siegel Journal: J Craniofac Surg Date: 1999-03 Impact factor: 1.046
Authors: Christopher M Bonfield; Lesley M Foley; Shinjini Kundu; Wendy Fellows-Mayle; T Kevin Hitchens; Gustavo K Rohde; Ramesh Grandhi; Mark P Mooney Journal: Neurosurg Focus Date: 2015-05 Impact factor: 4.047
Authors: Ramesh Grandhi; Geoffrey W Peitz; Lesley M Foley; Christopher M Bonfield; Wendy Fellows-Mayle; T Kevin Hitchens; Mark P Mooney Journal: PLoS One Date: 2018-06-01 Impact factor: 3.240