BACKGROUND: IGFBP-3 has been reported to be growth-stimulatory. The creation of tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed with the application of TMA to analyze the IGFBP-3 status in breast cancer with the hope to elucidate the possible relationship between IGFBP-3 expression and breast cancer biology. MATERIALS AND METHODS: Archival tissue specimens from 97 patients with primary invasive breast cancer were selected. The IGFBP-3 expression was analyzed by TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. RESULTS: There were 40 patients (41%) with 0-1 expression of IGFBP-3, 52 patients (54%) with 2 expression of IGFBP-3 and 5 patients (5%) with 3 expression in IGFBP-3. By multivariate analysis, the IGFBP-3 expression turned out to be significantly related to the overall five-year survival rate. CONCLUSION: The preliminary results about IGFBP-3 expression in breast cancer are intriguing and require further evaluation.
BACKGROUND:IGFBP-3 has been reported to be growth-stimulatory. The creation of tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed with the application of TMA to analyze the IGFBP-3 status in breast cancer with the hope to elucidate the possible relationship between IGFBP-3 expression and breast cancer biology. MATERIALS AND METHODS: Archival tissue specimens from 97 patients with primary invasive breast cancer were selected. The IGFBP-3 expression was analyzed by TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. RESULTS: There were 40 patients (41%) with 0-1 expression of IGFBP-3, 52 patients (54%) with 2 expression of IGFBP-3 and 5 patients (5%) with 3 expression in IGFBP-3. By multivariate analysis, the IGFBP-3 expression turned out to be significantly related to the overall five-year survival rate. CONCLUSION: The preliminary results about IGFBP-3 expression in breast cancer are intriguing and require further evaluation.
Authors: Brenda Y Hernandez; Lynne R Wilkens; Loïc Le Marchand; David Horio; Clayton D Chong; Lenora W M Loo Journal: Cancer Med Date: 2015-01-26 Impact factor: 4.452
Authors: Tiffany Scully; Sue M Firth; Carolyn D Scott; Hasanthi C de Silva; John E Pintar; Tailoi Chan-Ling; Stephen M Twigg; Robert C Baxter Journal: Oncotarget Date: 2016-08-23