OBJECTIVE: The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation. DESIGN AND METHODS: This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AF patients and healthy subjects. RESULTS: The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008). CONCLUSIONS: This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement.
OBJECTIVE: The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation. DESIGN AND METHODS: This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AFpatients and healthy subjects. RESULTS: The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008). CONCLUSIONS: This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement.