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Literature DB >> 19413434

Genetic variance in processing speed drives variation in aging of spatial and memory abilities.

Deborah Finkel¹, Chandra A Reynolds, John J McArdle, Fumiaki Hamagami, Nancy L Pedersen.

Abstract

Previous analyses have identified a genetic contribution to the correlation between declines with age in processing speed and higher cognitive abilities. The goal of the current analysis was to apply the biometric dual change score model to consider the possibility of temporal dynamics underlying the genetic covariance between aging trajectories for processing speed and cognitive abilities. Longitudinal twin data from the Swedish Adoption/Twin Study of Aging, including up to 5 measurement occasions covering a 16-year period, were available from 806 participants ranging in age from 50 to 88 years at the 1st measurement wave. Factors were generated to tap 4 cognitive domains: verbal ability, spatial ability, memory, and processing speed. Model-fitting indicated that genetic variance for processing speed was a leading indicator of variation in age changes for spatial and memory ability, providing additional support for processing speed theories of cognitive aging. Copyright 2009 APA, all rights reserved

Entities: Chemical Disease Gene Species

Mesh：

Year: 2009 PMID： 19413434 PMCID： PMC3742113 DOI： 10.1037/a0015332

Source DB: PubMed Journal: Dev Psychol ISSN： 0012-1649

27 in total

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18 in total

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Journal: Mol Psychiatry Date: 2015-04-14 Impact factor: 15.992