Literature DB >> 19413342

Lignans with anti-HIV activity from Schisandra propinqua var. sinensis.

Xiao-Nian Li1, Jian-Xin Pu, Xue Du, Liu-Meng Yang, Hui-Mei An, Chun Lei, Fei He, Xiao Luo, Yong-Tang Zheng, Yang Lu, Wei-Lie Xiao, Han-Dong Sun.   

Abstract

Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.

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Year:  2009        PMID： 19413342     DOI： 10.1021/np900123z

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

1.  Antioxidant Lignans and Neolignans from Acorus tatarinowii.

Authors:  Yuanyuan Lu; Yongbo Xue; Shenjie Chen; Hucheng Zhu; Jinwen Zhang; Xiao-Nian Li; Jianping Wang; JunJun Liu; Changxing Qi; Guang Du; Yonghui Zhang
Journal:  Sci Rep       Date:  2016-03-10       Impact factor: 4.379

2.  The Chemical Composition and Functional Properties of Essential Oils from Four Species of Schisandra Growing Wild in the Qinling Mountains, China.

Authors:  Xiaorui Wang; Yan Liu; Yuanyuan Niu; Nongxue Wang; Wei Gu
Journal:  Molecules       Date:  2018-07-05       Impact factor: 4.411

3.  In-silico Computational Investigations of AntiViral Lignan Derivatives as Potent Inhibitors of SARS CoV-2.

Authors:  Dipen K Sureja; Ashish P Shah; Normi D Gajjar; Shwetaba B Jadeja; Kunjan B Bodiwala; Tejas M Dhameliya
Journal:  ChemistrySelect       Date:  2022-07-26       Impact factor: 2.307

Review 4.  Demystifying racemic natural products in the homochiral world.

Authors:  Gabin Thierry M Bitchagno; Vaderament-A Nchiozem-Ngnitedem; Dennis Melchert; Serge Alain Fobofou
Journal:  Nat Rev Chem       Date:  2022-10-14       Impact factor: 34.571

Review 5.  Plant-derived lignans as potential antiviral agents: a systematic review.

Authors:  Xin-Ya Xu; Dong-Ying Wang; Yi-Ping Li; Stephen T Deyrup; Hong-Jie Zhang
Journal:  Phytochem Rev       Date:  2021-05-31       Impact factor: 7.741

Review 6.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923
  6 in total

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