| Literature DB >> 19413276 |
Evan J Horn1, Jacquelyn Gervay-Hague.
Abstract
Peracetylated Neu5Ac2en methyl ester, an intermediate in the synthesis of the influenza neuraminidase inhibitor Relenza, has been synthesized in high yields from peracetylated Neu5Ac methyl ester by flash vacuum pyrolysis. Mechanistic evidence including deuterium labeled studies and DFT (B3LYP) calculations suggest this transformation proceeds via an intramolecular syn-elimination.Entities:
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Year: 2009 PMID： 19413276 PMCID： PMC4557971 DOI： 10.1021/jo900224t
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354