PURPOSE: To report an unusual case of granulomatous sclerochoroiditis. DESIGN: Interventional case report. METHODS: A patient with ANCA-associated granulomatous vasculitis presented with nodular necrotizing scleritis, which was recalcitrant to multiple systemic immunosuppressive therapies and progressed to a blind painful eye, which was enucleated. RESULTS: Histopathology revealed extensive occlusive vasculitis, diffuse T- and B- cellular infiltration, and lymphoid granulomatous formation. Enhanced MHC class II antigens, adhesion molecules, and Fas (CD95) and FasL (CD95L) were detected in the lesion. CONCLUSION: Granulomatous sclerochoroiditis with aggressive immune reaction can be a complication of ANCA-associated granulomatous vasculitis.
PURPOSE: To report an unusual case of granulomatous sclerochoroiditis. DESIGN: Interventional case report. METHODS: A patient with ANCA-associated granulomatous vasculitis presented with nodular necrotizing scleritis, which was recalcitrant to multiple systemic immunosuppressive therapies and progressed to a blind painful eye, which was enucleated. RESULTS: Histopathology revealed extensive occlusive vasculitis, diffuse T- and B- cellular infiltration, and lymphoid granulomatous formation. Enhanced MHC class II antigens, adhesion molecules, and Fas (CD95) and FasL (CD95L) were detected in the lesion. CONCLUSION:Granulomatous sclerochoroiditis with aggressive immune reaction can be a complication of ANCA-associated granulomatous vasculitis.
Authors: Ashleigh L Levison; Careen Y Lowder; Kimberly M Baynes; Peter K Kaiser; Sunil K Srivastava Journal: Int Ophthalmol Date: 2015-11-23 Impact factor: 2.031