PURPOSE: The aim of this study was to compare the maximum-slope (MS) and dual-input one-compartment model (DOCM) methods in hepatic perfusion computed tomography (CT). MATERIALS AND METHODS: A total of 37 patients with known or suspected liver disease underwent single-location dynamic CT after arterial or venous bolus injection of contrast material. Perfusion CT images were created by the MS (dividing the peak gradient of the time-attenuation curve by the peak vessel CT number) and DOCM-calculating from the equation dC ( L )(t)/dt = k ( a ) C ( a )(t - tau( a )) + k ( p ) C ( p )(t - tau( p )) - k ( v ) C ( L )(t)-methods. The perfusion parameters hepatic arterial perfusion (HAP), portal venous perfusion (PVP), and hepatic perfusion index (HPI) were determined. RESULTS: The PVP of the tumor-free hepatic parenchyma determined by the MS method was lower than that obtained by the DOCM method (P < 0.001) with both injections. HAP determined by the MS method was lower than that obtained by the DOCM method with venous injection (P = 0.001), although there was no difference between the methods for HAP with arterial injection (P = 0.154). Most of the perfusion parameters showed linear correlations between the two analytical methods. CONCLUSION: Except for HAP with arterial injection, the perfusion parameters obtained with the MS method were lower than those obtained with the DOCM method.
PURPOSE: The aim of this study was to compare the maximum-slope (MS) and dual-input one-compartment model (DOCM) methods in hepatic perfusion computed tomography (CT). MATERIALS AND METHODS: A total of 37 patients with known or suspected liver disease underwent single-location dynamic CT after arterial or venous bolus injection of contrast material. Perfusion CT images were created by the MS (dividing the peak gradient of the time-attenuation curve by the peak vessel CT number) and DOCM-calculating from the equation dC ( L )(t)/dt = k ( a ) C ( a )(t - tau( a )) + k ( p ) C ( p )(t - tau( p )) - k ( v ) C ( L )(t)-methods. The perfusion parameters hepatic arterial perfusion (HAP), portal venous perfusion (PVP), and hepatic perfusion index (HPI) were determined. RESULTS: The PVP of the tumor-free hepatic parenchyma determined by the MS method was lower than that obtained by the DOCM method (P < 0.001) with both injections. HAP determined by the MS method was lower than that obtained by the DOCM method with venous injection (P = 0.001), although there was no difference between the methods for HAP with arterial injection (P = 0.154). Most of the perfusion parameters showed linear correlations between the two analytical methods. CONCLUSION: Except for HAP with arterial injection, the perfusion parameters obtained with the MS method were lower than those obtained with the DOCM method.
Authors: Lotfi Slimani; Nobuyuki Kudomi; Vesa Oikonen; M Jarvisalo; Jan Kiss; Alexandru Naum; Ronald Borra; Antti Viljanen; Hannu Sipila; Ele Ferrannini; Timo Savunen; Pirjo Nuutila; Patricia Iozzo Journal: J Hepatol Date: 2008-03-04 Impact factor: 25.083
Authors: Dushyant V Sahani; Sanjeeva P Kalva; Leena M Hamberg; Peter F Hahn; Christopher G Willett; Sanjay Saini; Peter R Mueller; Ting-Yim Lee Journal: Radiology Date: 2005-03 Impact factor: 11.105
Authors: Michael A Fischer; Herman P Marquez; Sonja Gordic; Bertil Leidner; Ernst Klotz; Peter Aspelin; Hatem Alkadhi; Torkel B Brismar Journal: Eur Radiol Date: 2016-07-01 Impact factor: 5.315