Literature DB >> 19411834

A novel mode of FoxM1 regulation: positive auto-regulatory loop.

Marianna Halasi1, Andrei L Gartel.   

Abstract

Oncogenic transcription factor FoxM1 represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Previously, we identified the thiazole antibiotics as potent inhibitors of FoxM1. Surprisingly, investigation of the mechanism of action of FoxM1 inhibitors revealed a novel mode of positive auto-regulation of FoxM1.

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Year:  2009        PMID： 19411834     DOI： 10.4161/cc.8.12.8708

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  67 in total

1.  p21 cooperates with DDB2 protein in suppression of ultraviolet ray-induced skin malignancies.

Authors:  Tanya Stoyanova; Nilotpal Roy; Shaumick Bhattacharjee; Dragana Kopanja; Ted Valli; Srilata Bagchi; Pradip Raychaudhuri
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

2.  Proteasome inhibitors suppress expression of NPM and ARF proteins.

Authors:  Bulbul Pandit; Andrei L Gartel
Journal:  Cell Cycle       Date:  2011-11-15       Impact factor: 4.534

3.  Thiostrepton, proteasome inhibitors and FOXM1.

Authors:  Andrei L Gartel
Journal:  Cell Cycle       Date:  2011-12-15       Impact factor: 4.534

4.  Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

Authors:  Vladimir Petrovic; Robert H Costa; Lester F Lau; Pradip Raychaudhuri; Angela L Tyner
Journal:  Cancer Biol Ther       Date:  2010-06-06       Impact factor: 4.742

5.  The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.

Authors:  Nagaratna S Hegde; Deborah A Sanders; Raphaël Rodriguez; Shankar Balasubramanian
Journal:  Nat Chem       Date:  2011-08-21       Impact factor: 24.427

6.  Targeting FOXM1 auto-regulation in cancer.

Authors:  Andrei L Gartel
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

7.  Opposing Roles of the Forkhead Box Factors FoxM1 and FoxA2 in Liver Cancer.

Authors:  Vaibhav Chand; Akshay Pandey; Dragana Kopanja; Grace Guzman; Pradip Raychaudhuri
Journal:  Mol Cancer Res       Date:  2019-02-27       Impact factor: 5.852

8.  Proteasome inhibitors suppress the protein expression of mutant p53.

Authors:  Marianna Halasi; Bulbul Pandit; Andrei L Gartel
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

9.  Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes.

Authors:  Muy-Teck Teh; Emilios Gemenetzidis; Tracy Chaplin; Bryan D Young; Michael P Philpott
Journal:  Mol Cancer       Date:  2010-02-26       Impact factor: 27.401

10.  FoxM1 is a general target for proteasome inhibitors.

Authors:  Uppoor G Bhat; Marianna Halasi; Andrei L Gartel
Journal:  PLoS One       Date:  2009-08-12       Impact factor: 3.240
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