| Literature DB >> 19411633 |
Seema Singhal1, Eric Vickrey, Jairam Krishnamurthy, Veerpal Singh, Sharon Allen, Jayesh Mehta.
Abstract
"Stringent" complete remission in myeloma has been defined by a normal serum free light chain ratio (SFLCR) in addition to the standard criteria for CR. 2648 serial samples from 122 IgG or IgA myeloma patients were studied to explore the relationship between SFLCR and serum immunofixation electrophoresis (SIFE). SFLCR was normal in 34% of cases with positive SIFE and abnormal in 66%. SFLCR was normal in 69% of cases with negative SIFE and abnormal in 31%. When evaluated with SIFE as the benchmark, the sensitivity of SFLCR was 66% and specificity was 69%. These findings were unchanged when abnormal SFLCR values were classified as concordant (< 0.26 for lambda disease and > 1.65 for kappa) or discordant (< 0.26 for kappa disease and > 1.65 for lambda). Additional studies are required to determine the temporal relationship between SFLCR normalization and paraprotein clearance. Until then, the role of SFLCR in defining response remains controversial.Entities:
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Year: 2009 PMID： 19411633 DOI： 10.1182/blood-2009-02-205807
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113