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Literature DB >> 19411066

Regulation of XIAP translation and induction by MDM2 following irradiation.

Lubing Gu¹, Ningxi Zhu, Hongying Zhang, Donald L Durden, Yue Feng, Muxiang Zhou.

Abstract

Increases in protein levels of XIAP in cancer cells have been associated with resistance to apoptosis induced by cellular stress. Herein we demonstrate that the upregulation of XIAP protein levels is regulated by MDM2 at the translational level. MDM2 was found to physically interact with the IRES of the XIAP 5'-UTR, and to positively regulate XIAP IRES activity. This XIAP IRES-dependent translation was significantly increased in MDM2-transfected cells where MDM2 accumulated in the cytoplasm. Cellular stress and DNA damage triggered by irradiation induced the dephosphorylation and cytoplasmic localization of MDM2, which also led to an increase in IRES-dependent XIAP translation. Upregulation of XIAP in MDM2-overexpressing cancer cells in response to irradiation resulted in resistance of these cells to radiation-induced apoptosis.

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Year: 2009 PMID： 19411066 PMCID： PMC2696306 DOI： 10.1016/j.ccr.2009.03.002

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

42 in total

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80 in total

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2. Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β.

Authors: Dechen Fu; Neena Lala-Tabbert; Hwabin Lee; Nadine Wiper-Bergeron
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Authors: A Stedman; S Beck-Cormier; M Le Bouteiller; A Raveux; S Vandormael-Pournin; S Coqueran; V Lejour; L Jarzebowski; F Toledo; S Robine; M Cohen-Tannoudji
Journal: Cell Death Differ Date: 2015-06-12 Impact factor: 15.828

Regulation of XIAP translation and induction by MDM2 following irradiation.

1. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.

Review 2. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

Review 3. Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression.

4. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.

5. The MDM2 oncoprotein binds specifically to RNA through its RING finger domain.

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7. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

8. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association.

9. Interaction between the retinoblastoma protein and the oncoprotein MDM2.

10. Demonstrating internal ribosome entry sites in eukaryotic mRNAs using stringent RNA test procedures.

1. Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivo.

2. Mdm2 promotes myogenesis through the ubiquitination and degradation of CCAAT/enhancer-binding protein β.

3. Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells.

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