| Literature DB >> 19411063 |
Chih-Cheng Yang1, Dieter A Wolf.
Abstract
Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFalpha-dependent NFkappaB activation induces COP9 signalosome-mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.Entities:
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Year: 2009 PMID： 19411063 DOI： 10.1016/j.ccr.2009.04.003
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743