Literature DB >> 19410474

Spectral performance of a composite single-crystal filtered thermal neutron beam for BNCT research at the University of Missouri.

J Brockman1, D W Nigg, M F Hawthorne, C McKibben.   

Abstract

Parameter studies, design calculations and initial neutronic performance measurements have been completed for a new thermal neutron beamline to be used for neutron capture therapy cell and small-animal radiobiology studies at the University of Missouri Research Reactor. The beamline features the use of single-crystal silicon and bismuth sections for neutron filtering and for reduction of incident gamma radiation. The calculated and measured thermal neutron fluxes produced at the irradiation location are 9.6 x 10(8) and 8.8 x 10(8)neutrons/cm(2)s, respectively. Calculated and measured cadmium ratios (Au foils) are 217 and 132. These results indicate a well-thermalized neutron spectrum with sufficient thermal neutron flux for a variety of small animal BNCT studies.

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Year:  2009        PMID: 19410474     DOI: 10.1016/j.apradiso.2009.03.108

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  2 in total

1.  Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes.

Authors:  Peter J Kueffer; Charles A Maitz; Aslam A Khan; Seth A Schuster; Natalia I Shlyakhtina; Satish S Jalisatgi; John D Brockman; David W Nigg; M Frederick Hawthorne
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-27       Impact factor: 11.205

2.  Validation and Comparison of the Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated By Boron-Rich Liposomes in Multiple Murine Tumor Models.

Authors:  Charles A Maitz; Aslam A Khan; Peter J Kueffer; John D Brockman; Jonathan Dixson; Satish S Jalisatgi; David W Nigg; Thomas A Everett; M Frederick Hawthorne
Journal:  Transl Oncol       Date:  2017-07-03       Impact factor: 4.243

  2 in total

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