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Literature DB >> 19410457

Structure-activity relationship studies of small-molecule inhibitors of Wnt response.

Jianming Lu¹, Zhiqiang Ma, Jen-Chieh Hsieh, Chih-Wei Fan, Baozhi Chen, Jamie C Longgood, Noelle S Williams, James F Amatruda, Lawrence Lum, Chuo Chen.

Abstract

Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.

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Year: 2009 PMID： 19410457 PMCID： PMC2709695 DOI： 10.1016/j.bmcl.2009.04.040

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

11 in total

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10. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.

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47 in total

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5. Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis in Drosophila.

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