BACKGROUND: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer. METHODS: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass' and Klintrup's criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time. RESULTS: Low-grade inflammatory infiltrate assessed using Klintrup's criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n=179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin. CONCLUSION: Assessment of inflammatory infiltrate using Klintrup's criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth.
BACKGROUND: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer. METHODS: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass' and Klintrup's criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time. RESULTS: Low-grade inflammatory infiltrate assessed using Klintrup's criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n=179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin. CONCLUSION: Assessment of inflammatory infiltrate using Klintrup's criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth.
Authors: Campbell Roxburgh; Alec McDonald; Jonathan Salmond; Karin Oien; John Anderson; Ruth McKee; Paul Horgan; Donald McMillan Journal: Int J Colorectal Dis Date: 2011-01-07 Impact factor: 2.571
Authors: Vanessa Deschoolmeester; Marc Baay; Eric Van Marck; Joost Weyler; Peter Vermeulen; Filip Lardon; Jan B Vermorken Journal: BMC Immunol Date: 2010-04-12 Impact factor: 3.615
Authors: Campbell S D Roxburgh; Jonathan M Salmond; Paul G Horgan; Karin A Oien; Donald C McMillan Journal: J Gastrointest Surg Date: 2009-09-19 Impact factor: 3.452
Authors: Lars Harbaum; Marion J Pollheimer; Peter Kornprat; Richard A Lindtner; Carsten Bokemeyer; Cord Langner Journal: Mod Pathol Date: 2014-09-12 Impact factor: 7.842