Literature DB >> 19409421

Kinetoplastid papain-like cysteine peptidases.

Conor R Caffrey1, Dietmar Steverding.   

Abstract

Cysteine peptidases are important for growth and survival of kinetoplastid parasites. The best characterised are those homologous to mammalian cathepsins B and L. To address a somewhat confusing terminology, we introduce a unifying nomenclature for kinetoplastid CATB and CATL peptidases. We review their evolutionary relatedness, genomic organisation, developmental expression, subcellular location and physiological functions. In addition, the applications of kinetoplastid CATB and CATL enzymes as vaccine candidates, diagnostic markers and drug targets are discussed.

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Year:  2009        PMID： 19409421     DOI： 10.1016/j.molbiopara.2009.04.009

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  16 in total

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Journal:  Curr Opin Microbiol       Date:  2012-03-23       Impact factor: 7.934

2.  Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity.

Authors:  Natalie A Stephens; Stephen L Hajduk
Journal:  Eukaryot Cell       Date:  2011-06-24

3.  African Trypanosome-Induced Blood-Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation.

Authors:  Brandon J Sumpio; Gautham Chitragari; Takeshi Moriguchi; Sherif Shalaby; Valeria Pappas-Brown; Asif M Khan; Shamala Devi Sekaran; Bauer E Sumpio; Dennis J Grab
Journal:  Int J Angiol       Date:  2014-06-09

4.  Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in Trypanosoma brucei.

Authors:  Jason S Silverman; Kevin J Schwartz; Stephen L Hajduk; James D Bangs
Journal:  Mol Microbiol       Date:  2011-09-30       Impact factor: 3.501

5.  Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis.

Authors:  Pei Liang; Lei He; Yanquan Xu; Xueqing Chen; Yan Huang; Mengyu Ren; Chi Liang; Xuerong Li; Jin Xu; Gang Lu; Xinbing Yu
Journal:  Parasitol Res       Date:  2014-08-21       Impact factor: 2.289

6.  Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum.

Authors:  Marcelo N Gomes; Laura M Alcântara; Bruno J Neves; Cleber C Melo-Filho; Lucio H Freitas-Junior; Carolina B Moraes; Rui Ma; Scott G Franzblau; Eugene Muratov; Carolina Horta Andrade
Journal:  Bioorg Med Chem Lett       Date:  2017-04-04       Impact factor: 2.823

7.  Intracellular trafficking and glycobiology of TbPDI2, a stage-specific protein disulfide isomerase in Trypanosoma brucei.

Authors:  Kevin J Schwartz; Ronald F Peck; James D Bangs
Journal:  Eukaryot Cell       Date:  2012-11-16

8.  Streamlined architecture and glycosylphosphatidylinositol-dependent trafficking in the early secretory pathway of African trypanosomes.

Authors:  Elitza S Sevova; James D Bangs
Journal:  Mol Biol Cell       Date:  2009-09-16       Impact factor: 4.138

Review 9.  The global cysteine peptidase landscape in parasites.

Authors:  Holly J Atkinson; Patricia C Babbitt; Mohammed Sajid
Journal:  Trends Parasitol       Date:  2009-10-24

10.  A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection.

Authors:  Momar Ndao; Milli Nath-Chowdhury; Mohammed Sajid; Victoria Marcus; Susan T Mashiyama; Judy Sakanari; Eric Chow; Zachary Mackey; Kirkwood M Land; Matthew P Jacobson; Chakrapani Kalyanaraman; James H McKerrow; Michael J Arrowood; Conor R Caffrey
Journal:  Antimicrob Agents Chemother       Date:  2013-09-23       Impact factor: 5.191
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