Literature DB >> 19408274

All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery.

Jae-Hyun Lee1, Kyuri Lee, Seung Ho Moon, Yuhan Lee, Tae Gwan Park, Jinwoo Cheon.   

Abstract

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

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Year:  2009        PMID： 19408274     DOI： 10.1002/anie.200805998

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  84 in total

1.  An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.

Authors:  Rajendra N Mitra; Mona Doshi; Xiaolei Zhang; Jessica C Tyus; Niclas Bengtsson; Steven Fletcher; Brent D G Page; James Turkson; Andre J Gesquiere; Patrick T Gunning; Glenn A Walter; Swadeshmukul Santra
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Review 2.  Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs.

Authors:  Yuejun Fu; Na An; Ke Li; Yali Zheng; Aihua Liang
Journal:  J Neurooncol       Date:  2011-11-23       Impact factor: 4.130

3.  pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells.

Authors:  Hyejung Mok; Omid Veiseh; Chen Fang; Forrest M Kievit; Freddy Y Wang; James O Park; Miqin Zhang
Journal:  Mol Pharm       Date:  2010-09-14       Impact factor: 4.939

Review 4.  Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence.

Authors:  Alyssa B Chinen; Chenxia M Guan; Jennifer R Ferrer; Stacey N Barnaby; Timothy J Merkel; Chad A Mirkin
Journal:  Chem Rev       Date:  2015-08-27       Impact factor: 60.622

Review 5.  Polymeric Nanostructures for Imaging and Therapy.

Authors:  Mahmoud Elsabahy; Gyu Seong Heo; Soon-Mi Lim; Guorong Sun; Karen L Wooley
Journal:  Chem Rev       Date:  2015-08-04       Impact factor: 60.622

Review 6.  Magnetic nanoparticles for cancer diagnosis and therapy.

Authors:  Mehmet V Yigit; Anna Moore; Zdravka Medarova
Journal:  Pharm Res       Date:  2012-01-25       Impact factor: 4.200

7.  Triblock copolymer-encapsulated nanoparticles with outstanding colloidal stability for siRNA delivery.

Authors:  Jian Qian; Xiaohu Gao
Journal:  ACS Appl Mater Interfaces       Date:  2013-01-15       Impact factor: 9.229

8.  In vivo safety evaluation of polyarginine coated magnetic nanovectors.

Authors:  Omid Veiseh; Forrest M Kievit; Vicki Liu; Chen Fang; Zachary R Stephen; Richard G Ellenbogen; Miqin Zhang
Journal:  Mol Pharm       Date:  2013-10-21       Impact factor: 4.939

9.  One-Step Multipurpose Surface Functionalization by Adhesive Catecholamine.

Authors:  Sung Min Kang; Nathaniel S Hwang; Jihyeon Yeom; Sung Young Park; Phillip B Messersmith; Insung S Choi; Robert Langer; Daniel G Anderson; Haeshin Lee
Journal:  Adv Funct Mater       Date:  2012-07-24       Impact factor: 18.808

10.  Selective inhibition of human brain tumor cells through multifunctional quantum-dot-based siRNA delivery.

Authors:  Jongjin Jung; Aniruddh Solanki; Kevin A Memoli; Ken-ichiro Kamei; Hiyun Kim; Michael A Drahl; Lawrence J Williams; Hsian-Rong Tseng; KiBum Lee
Journal:  Angew Chem Int Ed Engl       Date:  2010       Impact factor: 15.336
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