Literature DB >> 19408248

Regioselective and sequential reactivity of activated 2,5-diketopiperazines.

Daniel Farran1, Delphine Echalier, Jean Martinez, Georges Dewynter.   

Abstract

The electrophilic reactivity of Boc-DKPs has been studied. Thanks to Boc activation, the opening ability of carbonyl lactam groups is enhanced. According to experimental conditions, this enabled the synthesis of Boc-amino acid derivatives or original dipeptides via a regioselective and sequential way.

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Year:  2009        PMID: 19408248     DOI: 10.1002/psc.1139

Source DB:  PubMed          Journal:  J Pept Sci        ISSN: 1075-2617            Impact factor:   1.905


  2 in total

1.  An economical approach for peptide synthesis via regioselective C-N bond cleavage of lactams.

Authors:  Wataru Muramatsu; Hisashi Yamamoto
Journal:  Chem Sci       Date:  2022-04-26       Impact factor: 9.969

2.  Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides.

Authors:  Lena Huck; Juan F González; Elena de la Cuesta; J Carlos Menéndez
Journal:  Beilstein J Org Chem       Date:  2016-08-08       Impact factor: 2.883

  2 in total

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