Literature DB >> 19408

Fortimicins A and B, new aminoglycoside antibiotics. II. Isolation, physico-chemical and chromatographic properties.

R Okachi, S Takasawa, T Sato, S Sato, M Yamamoto, I Kawamoto, T Nara.   

Abstract

The aminoglycoside antibiotics fortimicins A and B produced by a naturally occurring strain Micromonospora sp. MK-70 were isolated from its fermentation beer. Fortimicins A and B were isolated as water-soluble, basic, white amorphous powders having molecular formula C17H35N5O6 and C15H32N4O5, respectively. Acid hydrolysis of fortimicin A indicated that it has one mole of glycine in its molecule while fortimicin B has not. Paper chromatography, silica-gel and carbon thin-layer chromatography revealed that fortimicins A and B are novel aminoglycoside antibiotics.

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Year:  1977        PMID: 19408     DOI: 10.7164/antibiotics.30.541

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  3 in total

Review 1.  Astonishing diversity of natural surfactants: 4. Fatty acid amide glycosides, their analogs and derivatives.

Authors:  Valery M Dembitsky
Journal:  Lipids       Date:  2005-07       Impact factor: 1.880

2.  Antibacterial activity of fortimicin A compared with those of five other aminoglycosides, and factors affecting susceptibility tests.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1981-01       Impact factor: 5.191

3.  Cell wall composition of Micromonospora olivoasterospora, Micromonospora sagamiensis, and related organisms.

Authors:  I Kawamoto; T Oka; T Nara
Journal:  J Bacteriol       Date:  1981-05       Impact factor: 3.490

  3 in total

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