Literature DB >> 19407969

Fluorenone alkaloid from Caulophyllum robustum Maxim. with anti-myocardial ischemia activity.

Sicen Wang1, Binyu Wen, Na Wang, Juntian Liu, Langchong He.   

Abstract

A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.

Entities:  

Mesh:

Substances:

Year:  2009        PMID: 19407969     DOI: 10.1007/s12272-009-1407-7

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN: 0253-6269            Impact factor:   4.946


  2 in total

1.  Imperatorin protects H9c2 cardiomyoblasts cells from hypoxia/reoxygenation-induced injury through activation of ERK signaling pathway.

Authors:  Bihong Liao; Ruimian Chen; Feng Lin; Aihuan Mai; Jie Chen; Huimin Li; Shaohong Dong; Zhenglei Xu
Journal:  Saudi Pharm J       Date:  2017-04-28       Impact factor: 4.330

Review 2.  Genus caulophyllum: an overview of chemistry and bioactivity.

Authors:  Yong-Gang Xia; Guo-Yu Li; Jun Liang; Bing-You Yang; Shao-Wa Lü; Hai-Xue Kuang
Journal:  Evid Based Complement Alternat Med       Date:  2014-05-04       Impact factor: 2.629

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.