OBJECTIVE: To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome (P-BH). METHODS:Eighty patients of P-BH were randomly assigned to two groups, 39 in Group A and 41 in Group B. Both was treated with Chinese herbal medicines for clearing heat, cooling blood and removing toxic substance, and acitretin capsule was given to Group A additionally, with 8 weeks as one therapeutic course. The clinical curative effect was compared between groups, and the change of psoriasis activity severe index (PASI) scores before and after treatment was observed. RESULTS: The total effective rate in Group A was 84.2% and that in Group B 68.2%, also showing significance between groups (P<0.01). PASI score lowered significantly after treatment in both groups, showing statistical significance (P<0.01), but no significant difference between groups. Little adverse reaction was found in Group B, while in Group A, the adverse reaction was of even milder degree, which could be alleviated by adjusting the herbal medicine and symptomatic treatment administration. CONCLUSIONS: The effect of Chinese herbal medicine combined with acitretin capsule was superior to Chinese herbal medicine alone in treating P-BH, but the adverse reaction of acitretin capsule could be alleviated by adjusting the herbs used. However, the result is waiting to be verified further by larger samples.
RCT Entities:
OBJECTIVE: To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome (P-BH). METHODS: Eighty patients of P-BH were randomly assigned to two groups, 39 in Group A and 41 in Group B. Both was treated with Chinese herbal medicines for clearing heat, cooling blood and removing toxic substance, and acitretin capsule was given to Group A additionally, with 8 weeks as one therapeutic course. The clinical curative effect was compared between groups, and the change of psoriasis activity severe index (PASI) scores before and after treatment was observed. RESULTS: The total effective rate in Group A was 84.2% and that in Group B 68.2%, also showing significance between groups (P<0.01). PASI score lowered significantly after treatment in both groups, showing statistical significance (P<0.01), but no significant difference between groups. Little adverse reaction was found in Group B, while in Group A, the adverse reaction was of even milder degree, which could be alleviated by adjusting the herbal medicine and symptomatic treatment administration. CONCLUSIONS: The effect of Chinese herbal medicine combined with acitretin capsule was superior to Chinese herbal medicine alone in treating P-BH, but the adverse reaction of acitretin capsule could be alleviated by adjusting the herbs used. However, the result is waiting to be verified further by larger samples.
Authors: Brian H May; Anthony L Zhang; Wenyu Zhou; Chuan-Jian Lu; Shiqiang Deng; Charlie C L Xue Journal: Chin J Integr Med Date: 2012-04-02 Impact factor: 1.978
Authors: Ying Luo; Yi Ru; Xiaoying Sun; Yaqiong Zhou; Yingyao Yang; Tian Ma; Rong Xu; Jie Chen; Mi Zhou; Kan Ze; Li Ju; Yanjiao Wang; Qingfeng Yin; Ruiping Wang; Bin Li; Xin Li Journal: Ann Transl Med Date: 2019-11
Authors: Xin Li; Qing-Qing Xiao; Fu-Lun Li; Rong Xu; Bin Fan; Min-Feng Wu; Min Zhou; Su Li; Jie Chen; Shi-Guang Peng; Bin Li Journal: Evid Based Complement Alternat Med Date: 2016-05-04 Impact factor: 2.629