BACKGROUND AND PURPOSE: Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH). METHODS: Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls. RESULTS: The patient population had significantly lower coated-platelet levels than the controls (mean+/-SD, 24.8+/-9.7% versus 32.9+/-12.6%, P=0.0035). CONCLUSIONS: Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH.
BACKGROUND AND PURPOSE: Coated-platelets are a subset of platelets with high procoagulant potential observed on dual agonist stimulation with collagen and thrombin. Failure to produce coated-platelets in animals results in a bleeding diathesis. With this background, we undertook a pilot study to investigate coated-platelet production in patients with spontaneous intracerebral hemorrhage (SICH). METHODS: Coated-platelet levels were determined in 26 patients with a diagnosis of SICH and 52 controls. RESULTS: The patient population had significantly lower coated-platelet levels than the controls (mean+/-SD, 24.8+/-9.7% versus 32.9+/-12.6%, P=0.0035). CONCLUSIONS: Decreased coated-platelet synthesis may be linked to the mechanisms involved in the events leading to SICH.
Authors: Bappaditya Ray; Vijay M Pandav; Eleanor A Mathews; David M Thompson; Lance Ford; Lori K Yearout; Bradley N Bohnstedt; Shuchi Chaudhary; George L Dale; Calin I Prodan Journal: Transl Stroke Res Date: 2017-12-09 Impact factor: 6.829
Authors: Muataz Ali Hamad; Krystin Krauel; Nancy Schanze; Nadine Gauchel; Peter Stachon; Thomas Nuehrenberg; Mark Zurek; Daniel Duerschmied Journal: Front Cardiovasc Med Date: 2022-04-07